I've been thinking about Darth Sidious/Palpatine talking about influencing midichlorians to create life, and the theories regarding Anakin being brought into being using this technique, then I got thinking about Padme's death. Padme was always a fighter so I find it hard to believe that she just "gave up" the will to live. We know she didn't die because of Anakin's force choke, so could Palpatine have influenced the midichlorians to END her life, then telling Vader he killed her, which would then fuel Vader's grief and despair and guilt spiralling him further into the dark side and then more powerful? I think this theory makes more sense than Padme just dying because she was heartbroken over Anakin cos I don't think she would have done that not when she'd just gave birth to twins. I think Darth Sidious had some involvement!