And what type of antagonist is going to plague ME4? The reapers are either-dead gone, hooked up the galaxy's population subconsious like ghost in the shell and are all helpfull, or being held in Check By Sheapards will. Kind of hard to top Civilization Extinction causeing machine demi-gods tens of millions of years old. So what next? the Krogan or Asari empire? and Agressive Expansionist Earth ala Elderscrolls Aldmiri Dominion? Machine uprising ala terminator? Social strife/corprate conspiricy ala Deus ex? The Masseffect story was intended to end, and we have seen what happens in videogames who go too long past its natural ending, Metal gear Solid, Resident Evil, how was Halo 4, I have heard everything between Great! and totaly unremarkable, (Apathy is the greated damnation of all, in my book). I would think they would do well with fleshing out Star Trek but thats just me.