Yeah, I only played two out of my six Sheps as full-on paragons (and even they fried the Weyrloc speaker and Sgt. Cathka). As a femShep/Garrus playthrough, missing the paragon interrupt with Harkin is particularly funny. "You're lucky. I would have shot you somewhere else." As far as Brooks, I haven't done it yet but if you take that route and miss the Renegade interrupt, one of your squadmates shoots her and then provides the requisite Bond one-liner. I also haven't tried out all the elevator conversations on that mission - I always take EDI plus the LI. Those are all pretty funny, although I think Tali and Liara have the best one.