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Sith Alchemy was the science of chemical manipulation of objects and organisms using Sith knowledge

The Sith alchemy had its origins in the formation of the Sith Order. A group of Dark Jedi discovered that they could use the Force to radically mutate creatures. Creatures Dark Jedi created caused the Hundred Year Darkness, the Dark Jedi exiling the Galactic Republic space, where they found the primitive Sith.
Sith Alchemy was initially used to increase the force of arms and armor (like the famous Sith swords) or genetically engineer and improve alien species, making them more dangerous and easily controlled by the Sith Lords. The most famous example of species affected by Sith alchemy is that of the Massassi. More sinister still, Sith alchemy was able to raise the dead to serve the Sith. Korriban zombies, and possibly undead Sith, were creations of this science. Naga Sadow wrote many texts on the art of Sith Alchemy. These were studied by Seviss Vaa, experiments which were responsible for creating the Leviathan of the Underworld.